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| Modern Genetic Analysis Chapter 14. Regulation of Gene Transcription Transcription: Gene Regulation in Eukaryotes an Overview Figure 14-27. An 11.5 transgenic mouse embryo contains recombinant DNA composed of a 258-bp mouse DNA sequence fused to the E. coli lacZ gene, which encodes the enzyme b -galactosidase. The 258-bp mouse DNA contains all of the cis-regulatory sequences necessary to direct expression of lacZ in muscle precursor cells, as revealed by the blue histochemical stain for b -galactosidase enzyme activity. The stained muscle precursors include the somites, limb buds, and branchial arches of the embryo. (Reproduced from D. J. Goldhamer, B. P. Brunk, A. Faerman, A. King, M. Shani, and C. P. Emerson, Jr., Development 121, 1995, 644.)

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