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Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Cancer: the Genetics of Aberrant Cell Control
Table 15-2. Some Well-Characterized Oncogenes and the Proteins That They Encode

| PROPERTIES OF PROTEIN

Oncogene | Location | Function

Nuclear transcription regulators |  |
jun | Nucleus | Transcription factor
fos | Nucleus | Transcription factor
erbA | Nucleus | Member of steroid receptor family
Intracellular signal transducers |  |
abl | Cytoplasm | Protein tyrosine kinase
raf | Cytoplasm | Protein serine kinase
gsp | Cytoplasm | G-protein a subunit
ras | Cytoplasm | GTP/GDP-binding protein
Mitogen |  |
sis | Extracellular | Secreted growth factor
Mitogen receptors |  |
erbB | Transmembrane | Receptor tyrosine kinase
fms | Transmembrane | Receptor tyrosine kinase
Apoptosis inhibitor |  |
bcl2 | Cytoplasm | Upstream inhibitor of caspase cascade

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