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| Modern Genetic Analysis Chapter 12. Genomics Structural Genomics Figure 12-11. Obtaining a DNA fingerprint by using a VNTR probe. (a) Preparation of the probe. The first intron of the myoglobin gene has four repeats of the sequence shown, which contains a 13-bp core sequence (shown in boldface). This core sequence is found at other VNTR loci, labeled VNTR I, II, and III in this simple diagrammatic representation. (b) The number of repeats at the three VNTR loci with the core sequence. The Southern blot has been probed with the 33-bp repeat in (a) and shows the DNA fingerprints of three people. (From J. D. Watson, M. Gilman, J. Witkowski, and M. Zoller, Recombinant DNA, 2d ed. Copyright © 1992 by James D. Watson, Michael Gilman, Jan Witkowski, and Mark Zoller.)

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