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| Modern Genetic Analysis Chapter 6. Gene Interaction A Diagnostic Test for Alleles Figure 6-2. Formation of a heterokaryon of Neurospora, demonstrating both complementation and recessiveness. Vegetative cells of this normally haploid fungus can fuse, allowing the nuclei from the two strains to intermingle within the same cytoplasm. If each strain is blocked at a different point in a metabolic pathway, as are arg-1 and arg-2 mutants, all functions are present in the heterokaryon and the Neurospora will grow; in other words, complementation takes place. The growth must be due to the presence of the wild-type gene; hence, the mutant genes arg-1 and arg-2 must be recessive.

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