Book Viewer

Short Contents | Full Contents | Other books @ NCBI

| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Controlling the Cell Proliferation and Death Machinery Figure 15-12. Positive extracellular control of apoptosis. A molecule such as Apaf is activated through binding of FasL (Fas ligand), anchored on the outside of an adjacent cell. FasL binds to the Fas transmembrane receptor on the cell that will undergo apoptosis. Apaf activation in turn causes proteolysis and activation of the initiator caspase. A series of caspases are then proteolysed and activated in turn, ultimately leading to apoptosis of the cell. (Adapted from S. Nagata, Cell 88, 1997, 357.)

© 1999 by W. H. Freeman and Company. All rights reserved.