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| Modern Genetic Analysis Chapter 7. Gene Mutations The Molecular Basis of Mutation Figure 7-11. (a) Structure of a cyclobutane pyrimidine dimer. Ultraviolet light stimulates the formation of a four-membered cyclobutyl ring (green) between two adjacent pyrimidines on the same DNA strand by acting on the 5,6 double bonds. (b) Structure of the 6-4 photo-product. The structure forms most prevalently with 5-C-C-3 and 5-T-C-3, between the C-6 and C-4 positions of two adjacent pyrimidines, causing a significant perturbation in local structure of the double helix. (Part a adapted from E. C. Friedberg, DNA Repair. Copyright © 1985 by W. H. Freeman. Part b from J. S. Taylor et al.)

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