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| Modern Genetic Analysis Chapter 12. Genomics Structural Genomics Figure 12-32. Producing lines for QTL identification and mapping. Two pure lines that differ significantly in some quantitative trait (character) are crossed, and, after many generations of inbreeding, pure recombinant lines are produced. The comparison of phenotypes of these lines leads to the identification of specific chromosomal segments that consistently contribute to the parental difference. These regions contain presumptive QTLs. (Based on W. N. Frankel, "Taking Stock of Complex Trait Genetics in Mice," Trends in Genetics 12, 1995, Fig. 1.)

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