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| Modern Genetic Analysis Chapter 7. Gene Mutations Mutational Analysis Figure 7-36. A detection system for recessive somatic mutations at seven coat color loci in mice. The cross ln / ln; pa / pa; b+ / b+; ch+ / ch+; p+ / p+; d+ / d+; pe / pe × ln+ / ln+; pa+ / pa+; b / b; ch / ch; p / p; d / d; pe+ / pe+ results in progeny heterozygous for all seven genes and predominantly wild-type in appearance. Any somatic mutation from wild type to mutant at any of the loci causes a mutant sector in the coat of the offspring. The mutant colors are leaden (ln), pallid (pa), brown (b), chinchilla (ch), pink-eyed dilution (p), dilution (d), and pearl (pe). The frequency of mutations can be increased by administering to developing embryos a chemical that is known to produce mutations (a chemical mutagen).

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