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| Modern Genetic Analysis Chapter 5. Recombination of Genes The Mechanism of Crossing-Over Figure 5-18. The Meselson-Radding heteroduplex model. (a) A duplex is cut on one chain. (b) DNA polymerase displaces one chain. (c) The resulting single chain displaces its counterpart in the homolog. (d) This displaced chain is enzymatically digested. (e) Ligation completes the formation of a Holliday junction, which is genetically asymmetric in that only one of the two duplexes has a region of potentially heteroduplex DNA. If the junction migrates, heteroduplex DNA can arise on both duplexes. (f) Resolution of the junction occurs as in the Holliday model. (From F. W. Stahl, "The Holliday Junction on Its Thirtieth Anniversary," Genetics 138, 1994, 241246.)

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