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| Modern Genetic Analysis Chapter 12. Genomics Structural Genomics Figure 12-14. Repetitive elements found in the human gene (HGO) coding for homogentisate 1,2-dioxygenase, the enzyme whose deficiency causes alkaptonuria. The first line diagrams the position of the HGO exons. The location and direction of Alus (blue), SINEs (purple), LINEs (orange), retrotransposon-derived sequences (LTRs, red), and short-sequence repeats (SSRs, maroon) in the HGO sequence are indicated by color. (Modified from B. Granadino, D. Beltrán-Valero de Bernabé, J. M. Fernández-Cañón, M. A. Peñalva, and S. Rodríguez de Córdoba, "The Human Homogentisate 1,2-Dioxygenase (HGO) Gene," Genomics 43, 1997, 115.)

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