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| Modern Genetic Analysis Chapter 7. Gene Mutations The Molecular Basis of Mutation Figure 7-10. DNA polymerase III, shown in blue, stops at a non-coding lesion, such as the T·C photodimer shown here, generating single-stranded regions that attract the Ssb protein (dark purple) and RecA (light purple), which forms filaments. The presence of RecA filaments helps to signal the cell to synthesize UmuD (red circles), which is cleaved by RecA to yield UmuD (pink circles) and UmuC (yellow ovals). The UmuC is recruited to form a complex with UmuD that permits DNA polymerase III to proceed past the blocking lesion.

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