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| Modern Genetic Analysis Chapter 7. Gene Mutations The Molecular Basis of Mutation Figure 7-14. The distribution of 140 spontaneous mutations in lacI. Each occurrence of a point mutation is indicated by a box. Red boxes designate fast-reverting mutations. Deletions (gold) are represented below. The I map is given in terms of the amino acid number in the corresponding I-encoded Lac repressor. Allele numbers refer to mutations that have been analyzed at the DNA sequence level. The mutations S114 and S58 (blue circles) result from the insertion of transposable elements (see Chapter 13). S28 (red circle) is a duplication of 88 base pairs. (From P. J. Farabaugh, U. Schmeissner, M. Hofer, and J. H. Miller, Journal of Molecular Biology 126, 1978, 847.)

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