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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Cancer: the Genetics of Aberrant Cell Control Figure 15-16. The Ras oncoprotein. (a) The ras oncogene differs from the wild type by a single base pair, producing a Ras oncoprotein that differs from the wild type in one amino acid, at position 12 in the ras open reading frame. (b) The effect of this missense mutation is to create a Ras oncoprotein that cannot hydrolyze GTP to GDP (compare with the normal Ras cycle depicted in Figure 15-10). Because of this defect, the Ras oncoprotein remains in the active RasGTP complex and continuously activates the down-stream serine/threonine kinase (see Figure 15-11).

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