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| Modern Genetic Analysis Chapter 2. The Structure of Genes and Genomes The Nature of Eukaryotic Nuclear Chromosomes Figure 2-21. Electron micrograph of a metaphase chromosome from a cultured human cell. Note the central core, or scaffold, from which the DNA strands extend outward. No free ends are visible at the outer edge. At even higher magnification, it is clear that each loop begins and ends near the same region of the scaffold. (From W. R. Baumbach and K. W. Adolph, Cold Spring Harbor Symp. Quant. Biol., Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1977.)

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