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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells The Cell Proliferation Machinery Figure 15-2. A current view of the variations in cyclinCDK activities throughout the cell cycle of a mammalian cell. The widths of the bands indicate the relative kinase activities of the various cyclinCDK complexes. Note that several different cyclins (A, B, D, and E) and several different CDKs (Cdc2, Cdk2, Cdk4, and Cdk5) can bind to one another to form different complexes, increasing the array of combinations of cyclinCDK complexes that can form in the course of the cell cycle. (From H. Lodish, D. Baltimore, A. Berk, S. L. Zipursky, P. Matsudaira, and J. Darnell, Molecular Cell Biology, 3d ed. Copyright © 1995 by Scientific American Books.)

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