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| Modern Genetic Analysis Chapter 8. Chromosome Mutations Changes in Chromosome Number Figure 8-3. The use of colchicine to generate a diploid from a monoploid. Colchicine added to mitotic cells during metaphase and anaphase disrupts spindle fiber formation, preventing the migration of chromatids after the centromere is split. A single cell is created that contains pairs of identical chromosomes that are homozygous at all loci.

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