Book Viewer

Short Contents | Full Contents | Other books @ NCBI

| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Cancer: the Genetics of Aberrant Cell Control Figure 15-21. The major pathways that are mutated to contribute to cancer formation and progression. The main events that contribute to tumor formation are increased cell proliferation and cell survival (decreased apoptosis). The pathways in red are susceptible to gain-of-function oncogene mutation. The pathways in blue are susceptible to loss-of-function tumor-suppressor gene mutation.

© 1999 by W. H. Freeman and Company. All rights reserved.