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| Modern Genetic Analysis Chapter 11. Applications of Recombinant DNA Technology Expressing Eukaryotic Genes in Bacteria Figure 11-7. Expression of human growth hormone (hGH) in E. coli. (a) The human signal sequence is removed, enabling the protein to be produced in bacterial cells. The product contains an extra bacterial methionine. (b) A bacterial signal sequence that targets the protein for secretion to the outside can be added. In this method, the product has no extra methionine. (Copyright © 1992 by J. D. Watson, M. Gilman, J. Witkowski, and M. Zoller, Recombinant DNA, 2d ed. Scientific American Books.)

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