Book Viewer

Short Contents | Full Contents | Other books @ NCBI

| Modern Genetic Analysis Chapter 14. Regulation of Gene Transcription Regulation of the Lactose System Figure 14-11. Specific DNA sequences are important for efficient transcription of E. coli genes by RNA polymerase. The boxed sequences at approximately 35 and 10 nucleotides before the transcription start site are highly conserved in all E. coli promoters, an indication of their role as contact sites on the DNA for RNA polymerase binding. Mutations in these regions have mild (gold) and severe (brown) effects on transcription. The mutations may be changes of single nucleotides or pairs of nucleotides, or a deletion (D) may occur. (From J. D. Watson, M. Gilman, J. Witkowski, and M. Zoller, Recombinant DNA, 2d ed. Copyright © 1992 by James D. Watson, Michael Gilman, Jan Witkowski, and Mark Zoller.)

© 1999 by W. H. Freeman and Company. All rights reserved.