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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells The Cell Proliferation Machinery Figure 15-1. The steps in phosphorylation of target proteins by the cyclinCDK complex. First, a cyclin and a CDK subunit bind to form an active cyclinCDK complex. Then, the target protein binds to the cyclin part of the complex, placing the target phosphorylation sites in proximity to the active site of CDK. The target protein is then phosphorylated; it is then no longer able to bind to cyclin and is released from the complex.

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