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| Modern Genetic Analysis Chapter 8. Chromosome Mutations A reciprocal translocation demonstrated by a technique called chromosome painting. A suspension of chromosomes from many cells is passed through an electronic device that sorts them by size. DNA is extracted from individual chromosomes, joined to one of several fluorescent dyes, then added to partially denatured chromosomes on a slide. The fluorescent DNA "finds" its own chromosome and binds along its length to paint it. In this preparation a light-blue and a pink dye have been used to paint different chromosomes. The preparation shows one normal pink chromosome, one normal blue, and two that have exchanged their tips. (Lawrence Berkeley Laboratory)

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