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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells The Cell Proliferation Machinery Figure 15-3. The contributions of the Rb and E2F proteins in the regulation of the G1-to-S-phase transition in a mammalian cell. (From H. Lodish, D. Baltimore, A. Berk, S. L. Zipursky, P. Matsudaira, and J. Darnell, Molecular Cell Biology, 3d ed. Copyright © 1995 by Scientific American Books.)

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