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| Modern Genetic Analysis Chapter 7. Gene Mutations The Molecular Basis of Mutation Figure 7-8. Intercalating agents. (a) Structures of the common agents proflavin, acridine orange, and ICR-191. (b) An intercalating agent slips between the nitrogenous bases stacked at the center of the DNA molecule. This occurrence can lead to single-nucleotide-pair insertions and deletions. (From L. S. Lerman, Proceedings of the National Academy of Sciences USA 49, 1963, 94.)

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