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| Modern Genetic Analysis Chapter 11. Applications of Recombinant DNA Technology Using Recombinant DNA to Detect Disease Alleles Directly Figure 11-27. Detection of the sickle-cell globin gene by Southern blotting. The base change (A T) that causes sickle-cell anemia destroys an MstII target site that is present in the normal b -globin gene. This difference can be detected by Southern blotting. (Modified from Recombinant DNA, 2d ed. Scientific American Books. Copyright © 1992 by J. D. Watson, M. Gilman, J. Witkowski, and M. Zoller.)

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