Book Viewer

Short Contents | Full Contents | Other books @ NCBI

| Modern Genetic Analysis Chapter 16. The Genetic Basis of Development The Many Parallels in Vertebrate and Insect Pattern Formation Figure 16-33. The phenotype of a homeotic mutant mouse. Mice homozygous for a targeted knockout of the Hoxc-8 gene were created by using cultured ES cells. (a) An enlargement of the thoracic and lumbar vertebrae of a homozygous Hoxc-8 mouse. Note the ribs coming from L1, the first lumbar vertebra. L1 in wild-type mice had no ribs. (b) An unexpected second phenotype of the Hoxc-8 knockout. Note that the homozygous mutant mouse on the right has clenched fingers, whereas the wild-type mouse on the left has normal fingers. (From H. Le Mouellic, Y. Lallemand, and P. Brulet, Cell 69, 1992, 251.)

© 1999 by W. H. Freeman and Company. All rights reserved.