Book Viewer

Short Contents | Full Contents | Other books @ NCBI

| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Cancer: the Genetics of Aberrant Cell Control Figure 15-18. The chromosome rearrangement in CML. The Philadelphia chromosome, which is diagnostic of CML, is a translocation between chromosomes 9 and 22. The translocation break-points are in the middle of the c-abl gene, which encodes a cytoplasmic protein tyrosine kinase, and the bcr1 gene, which is also thought to be a protein kinase. The translocation produces a hybrid Bcr1-Abl protein that lacks the normal controls repressing the c-abl-encoded protein tyrosine kinase activity. Only one of the two rearranged chromosomes of the reciprocal translocation is shown. (Adapted from J. D. Watson, M. Gilman, J. Witkowski, and M. Zoller, Recombinant DNA, 2d ed. Copyright © 1992 by James D. Watson, Michael Gilman, Jan Witkowski, and Mark Zoller.)

© 1999 by W. H. Freeman and Company. All rights reserved.