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| Modern Genetic Analysis Chapter 13. Transposable Genetic Elements Mechanism of Transposition Figure 13-12. Transposition of Tn3 takes place through a cointegrate intermediate. Cointegrates in Tn3 transposition are observed for some internal deletions in the transposon. The correct explanation for this observation is that the cointegrates are intermediates in Tn3 transposition and that their resolution is blocked because the internal deletion has removed an internal resolution site (IRS), where recombi-nation takes place. (From F. Heffron, in J. A. Shapiro, ed., Mobile Genetic Elements, pp. 223260. Copyright © 1983 by Academic Press.)

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