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| Modern Genetic Analysis Chapter 8. Chromosome Mutations Evolution of the Genome Figure 8-29. (a) Functional interactions of hemoglobin genes in humans. Each Greek letter represents a different gene locus and the hemoglobin subunit determined by that gene. These subunits combine in different ways at different stages in development, as indicated, to yield functioning hemoglobin molecules. Notice that adults have a minor hemoglobin, a 2 d 2 (<2 percent) in addition to a 2 b 2. (b) Evolution of hemoglobins and myoglobin by duplication. (c) Proposed generation of variant human hemoglobin subunits by unequal crossing-over in the g - d - b genetic region. Notice that both Lepore and Kenya are deletions. (Parts a and c from D. J. Weatherall and J. B. Clegg, "Recent Developments in Molecular Genetics of Human Hemoglobin," Cell 16, 1979.)

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