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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells The Machinery or Programmed Cell Death Figure 15-4. The sequence of phenotypic events in apoptosis. First, the membranes of organelles such as mitochondria are disrupted and their contents leak into the cytoplasm, chromosomal DNA becomes fragmented into small pieces, and the cell loses its normal shape. Then, the cell breaks apart into small cell fragments and is disposed of by phagocytotic scavenger cells.

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