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| Modern Genetic Analysis Chapter 16. The Genetic Basis of Development Forming Complex Pattern: Establishing Positional Information Figure 16-15. The effect of replacement of the 3 UTR of the nanos mRNA with the 3 UTR of the bicoid mRNA on mRNA localization and embryonic phenotypes. (a) The structure of the nos-bcd 3 UTR transgene. (b) The effects on embryonic development of the transgene. The embryos and larva in the left column are derived from wild-type mothers. Those in the right column are derived from transgenic mothers. All embryos are shown with anterior to the left and posterior to the right. The exoskeletons are shown for comparison. The transgene causes a perfect mirror-image double abdomen. In the embryo from a transgenic mother, mRNAs coding for NOS protein are now present at both poles of the embryo. NOS protein will inhibit translation of hb-m mRNA (and, actually, of bcd mRNA as well). (From E. R. Gavis and R. Lehmann, Cell 71, 1992, 303.)

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