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| Modern Genetic Analysis Chapter 14. Regulation of Gene Transcription Metabolic Pathways Figure 14-18. The chromosomal order of genes in the trp operon of E. coli and the sequence of reactions catalyzed by the enzyme products of the trp structural genes. The products of genes trpD and trpE form a complex that catalyzes specific steps, as do the products of genes trpB and trpA. Tryptophan synthetase is a tetrameric enzyme formed by the products of trpB and trpA. It catalyzes a two-step process leading to the formation of tryptophan. (PRPP = phosphoribosyl pyrophosphate; CDRP = 1-(o-carboxyphenylamino)-1-deoxyribulose 5-phosphate.) (After S. Tanemura and R. H. Bauerle, Genetics 95, 1980, 545.)

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