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| Modern Genetic Analysis Chapter 12. Genomics Structural Genomics Figure 12-19. Linkage map of human chromosome 1, correlated with chromosome banding pattern. The histogram shows the distribution of all markers available for chromosome 1. Some markers are genes of known phenotype, but most are DNA markers based on neutral sequence variation. A linkage map, based on recombinant frequency analyses of the type described in this chapter, is in the center of the figure. It shows only some of the markers available. Map distances are shown in centimorgans (cM) (= m.u.). The total length of the chromosome 1 map is 356 cM; it is the longest human chromosome. The positions of some markers are cross-referenced to a diagram of subregions of chromosome 1 based on standard banding pattern (such a diagram is called an idiogram). These kinds of correlations can be made only by using cytogenetic analysis (Chapter 8) and in situ hybridization. Most of the markers shown on the map are molecular, but several genes (highlighted in light green) also are included: APOA2 apolipoprotein ACTN2 actin protein CRP C-reactive protein SPTA1 spectrin protein (B. R. Jasney et al., Science, Sept. 30, 1994.)

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