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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Cancer: the Genetics of Aberrant Cell Control Figure 15-19. The chromosomal rearrangement in follicular lymphoma. The translocation fuses the transcriptional enhancer element of a gene, on chromosome 14, that makes one protein subunit of an antibody (the IgH subunit, also called the immunoglobulin heavy chain) to the transcription unit of a gene, on chromosome 18, that encodes Bcr2, a negative regulator of apoptosis. In this way, the Bcr2 protein is produced in antibody-producing cells, blocking any self-destruction signals from inducing apoptosis in those cells.

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