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| Modern Genetic Analysis Chapter 15. Regulation of Cell Number: Normal and Cancer Cells Cancer: the Genetics of Aberrant Cell Control Figure 15-15. The multistep progression to malignancy in cancers of the colon and brain. Several histologically distinct stages can be distinguished in the progression of these tissues from the normal state to benign tumors to a malignant cancer. (a) A common sequence of mutational events in the progression to colon cancer. Note that the tissue becomes more disorganized as the tumor progresses toward malignancy. (b) A different characteristic series of mutations marks the progression toward a malignant astrocytoma, a form of brain cancer. (Micrographs by E. R. Fearon and K. Cho. From W. K. Cavanee and R. L. White, Scientific American, March 1995, 7879.)

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