Book Viewer

Short Contents | Full Contents | Other books @ NCBI

| Modern Genetic Analysis Chapter 16. The Genetic Basis of Development Forming Complex Pattern: Establishing Positional Information Figure 16-19. The two general classes of positional information. (a) Asymmetric organization of the cytoskeletal system permits localization of mRNA encoding a transcription factor that will provide positional information. Translation of the anchored mRNA will lead to diffusion of the newly translated transcription factor and the formation of a transcription factor gradient with a high point near the site of the mRNA. (b) Secretion of a positional information-signaling molecule from a localized source activates the signal transduction apparatus and the target transcription factors according to the level of signaling molecule that binds to its transmembrane receptor.

© 1999 by W. H. Freeman and Company. All rights reserved.